Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10803248 | 0.98 | LMNA (0.60) | PTGS2LMNACYP3A4KMT2AMEN1 | |
| SCHEMBL6737922 | 0.98 | LMNA (0.60) | PTGS2LMNACYP3A4KMT2AMEN1 | |
| SCHEMBL27645083 | 0.95 | PTGS2 (0.59) | PTGS2LMNACYP3A4KMT2AMEN1 | |
| SCHEMBL7635985 | 0.94 | LMNA (0.56) | PTGS2LMNACYP3A4KMT2AMEN1 | |
| SCHEMBL898711 | 0.88 | LMNA (0.59) | LMNACYP3A4KMT2AMEN1NR1I2 | |
| SCHEMBL898712 | 0.86 | LMNA (0.58) | LMNACYP3A4KMT2AMEN1NR1I2 | |
| SCHEMBL8081153 | 0.85 | LMNA (0.56) | LMNACYP3A4KMT2AMEN1NR1I2 | |
| SCHEMBL1963883 | 0.85 | LMNA (0.60) | LMNACYP3A4KMT2AMEN1NR1I2 | |
| SCHEMBL5613698 | 0.85 | LMNA (0.60) | LMNACYP3A4KMT2AMEN1NR1I2 | |
| SCHEMBL10904542 | 0.84 | LTA4H (0.51) | PTGS2LMNACYP3A4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3340979-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | The Texas A&M University System (US) | 2018-07-04 | — | — | EP | claimed |
| WO-2017035438-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2017-03-02 | — | — | WO | claimed |
| EP-3340979-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | The Texas A&M University System (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017035438-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2017-03-02 | — | — | WO | disclosed |