Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 5/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | IRS1 | P35568 | 2/20 | 0.34 |
| ▸ | GAB1 | Q13480 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1853297 | 0.89 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1TSHRHTTKMT2A | |
| SCHEMBL1852856 | 0.88 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1TSHRHTTKMT2A | |
| SCHEMBL4019783 | 0.82 | MAPK1 (0.41) | SMN1; SMN2TSHRKMT2AS1PR1S1PR3 | |
| SCHEMBL1854854 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1TSHRHTTKMT2A | |
| SCHEMBL4016045 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1TSHRHTTKMT2A | |
| SCHEMBL1852710 | 0.79 | FAAH (0.47) | S1PR1S1PR3NPSR1 | |
| SCHEMBL1853972 | 0.79 | MLYCD (0.52) | SMN1; SMN2MEN1HTTKMT2AL3MBTL1 | |
| SCHEMBL1849810 | 0.79 | MLYCD (0.52) | SMN1; SMN2MEN1HTTKMT2AL3MBTL1 | |
| SCHEMBL1852234 | 0.79 | HTT (0.51) | SMN1; SMN2MEN1TSHRHTTKMT2A | |
| SCHEMBL1854357 | 0.78 | FAAH (0.46) | S1PR1S1PR3NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | disclosed |
| US-7592477-B2 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases (PTPs) | LABORATOIRES SERONO SA (CH) | 2009-09-22 | — | — | US | disclosed |
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | APPLIED RESEARCH SYSTEMS ARS (NL) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124656-A1 | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases(ptps) | PTPRS, PTPA, PTPMT1 | SMN1; SMN2 4878/4885MEN1 2496/4885TSHR 1096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.