Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.42 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3627479 | 0.93 | ALDH1A1 (0.62) | ALDH1A1TDP1OPRM1LMNACACNA2D1 | |
| SCHEMBL17135388 | 0.85 | LMNA (0.50) | ALDH1A1TDP1OPRM1LMNASPHK1 | |
| SCHEMBL1991265 | 0.84 | ALDH1A1 (0.56) | ALDH1A1TDP1OPRM1LMNASPHK1 | |
| SCHEMBL11726366 | 0.83 | CACNA2D1 (0.46) | ALDH1A1TDP1CACNA2D1CACNB3CACNA1C | |
| SCHEMBL24218208 | 0.83 | CACNA2D1 (0.46) | ALDH1A1TDP1CACNA2D1CACNB3CACNA1C | |
| SCHEMBL5683598 | 0.83 | LMNA (0.54) | OPRM1LMNASPHK1DNM1TSHR | |
| SCHEMBL20821296 | 0.83 | LMNA (0.54) | OPRM1LMNASPHK1DNM1TSHR | |
| SCHEMBL22471932 | 0.83 | LMNA (0.54) | OPRM1LMNASPHK1DNM1TSHR | |
| SCHEMBL29640413 | 0.83 | LMNA (0.54) | OPRM1LMNASPHK1DNM1TSHR | |
| SCHEMBL6554193 | 0.83 | LMNA (0.48) | ALDH1A1TDP1OPRM1LMNASPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9579325-B2 | Modulators of TNF-α signaling | GENZYME CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |