Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 8/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28896602 | 0.86 | MPO (0.65) | MPOOPRM1TSHRALDH1A1CYP1A2 | |
| Verdiperstat SCHEMBL1536607 | 0.80 | MPO (1.00) | MPOOPRM1TPOCYP3A4KCNH2 | |
| SCHEMBL28896358 | 0.76 | MPO (0.61) | MPOOPRM1TSHRALDH1A1CYP1A2 | |
| SCHEMBL28896613 | 0.73 | MPO (0.61) | MPOOPRM1TSHRALDH1A1CYP1A2 | |
| SCHEMBL1776521 | 0.73 | MPO (0.61) | MPOOPRM1TSHRALDH1A1CYP1A2 | |
| SCHEMBL28896664 | 0.73 | MPO (0.58) | MPOOPRM1TSHRALDH1A1CYP1A2 | |
| SCHEMBL28959839 | 0.72 | MPO (0.60) | MPOOPRM1TSHRALDH1A1CYP1A2 | |
| SCHEMBL27101979 | 0.72 | MPO (0.57) | MPOOPRM1TSHRALDH1A1CYP1A2 | |
| SCHEMBL28896658 | 0.72 | MPO (0.57) | MPOOPRM1TSHRALDH1A1CYP1A2 | |
| SCHEMBL23225719 | 0.72 | MPO (0.56) | MPOOPRM1TSHRALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11738027-B2 | MPO inhibitors for use in medicine | ASTRAZENECA AB (SE) | 2023-08-29 | — | — | US | disclosed |
| US-20220160715-A1 | MPO INHIBITORS FOR USE IN MEDICINE | ASTRAZENECA AB (SE) | 2022-05-26 | — | — | US | disclosed |
| US-11246870-B2 | MPO inhibitors for use in medicine | ASTRAZENCA AB (SE) | 2022-02-15 | — | — | US | disclosed |
| US-9580429-B2 | Pyrrolo[3,2-D]pyrimidin-4-one derivatives and their use in therapy | ASTRAZENECA AB (SE) | 2017-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11738027-B2 | MPO inhibitors for use in medicine | MPO, SERPINB1, MMP8 | MPO 1/4885OPRM1 396/4885TSHR 1888/4885 |
| US-11246870-B2 | MPO inhibitors for use in medicine | MPO, SERPINB1, MMP8 | MPO 1/4885OPRM1 396/4885TSHR 1888/4885 |
| US-20220160715-A1 | MPO INHIBITORS FOR USE IN MEDICINE | MPO, SERPINB1, MMP8 | MPO 1/4885OPRM1 396/4885TSHR 1888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.