SCHEMBL18559049

SCHEMBL18559049

CCOC(=O)c1cccc(NC(=O)CSc2nnc(-c3cccnc3)n2C)c1

nearest known ligand 0.82

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.82
▸ USP2 O75604 1/20 0.82
▸ RECQL P46063 1/20 0.66
▸ L3MBTL1 Q9Y468 1/20 0.66
▸ LMNA P02545 2/20 0.64
▸ POLB P06746 1/20 0.64
▸ MEN1 O00255 2/20 0.63
▸ KMT2A Q03164 2/20 0.63
▸ TSHR P16473 2/20 0.62
▸ MAPK1 P28482 1/20 0.62
▸ SMN1; SMN2 Q16637 1/20 0.62
▸ MAPT P10636 2/20 0.61
▸ GAA P10253 1/20 0.59
▸ RAB9A P51151 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18559054 0.90 ALDH1A1 (1.00) ALDH1A1USP2RECQLLMNAKMT2A
SCHEMBL18559050 0.90 L3MBTL1 (0.75) ALDH1A1USP2RECQLL3MBTL1LMNA
SCHEMBL15986567 0.88 ALDH1A1 (0.68) ALDH1A1USP2RECQLL3MBTL1LMNA
SCHEMBL18559126 0.84 ALDH1A1 (1.00) ALDH1A1USP2LMNAMEN1KMT2A
SCHEMBL18559200 0.84 RECQL (0.80) ALDH1A1USP2RECQLL3MBTL1KMT2A
SCHEMBL18559273 0.84 RECQL (0.83) ALDH1A1RECQLL3MBTL1LMNAPOLB
SCHEMBL15983456 0.83 POLB (0.65) ALDH1A1USP2RECQLL3MBTL1LMNA
SCHEMBL15986072 0.81 RECQL (0.85) ALDH1A1RECQLL3MBTL1LMNAPOLB
SCHEMBL18559113 0.80 RECQL (0.79) ALDH1A1RECQLL3MBTL1LMNAPOLB
SCHEMBL15986464 0.80 RECQL (1.00) ALDH1A1RECQLL3MBTL1LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230136150-A1 Compositions for Inhibition of Insect Sensing UNIV VANDERBILT (US) 2023-05-04 — — US disclosed
US-20210219551-A1 Compositions for Inhibition of Insect Sensing VANDERBILT UNIVERSITY 2021-07-22 — — US disclosed
US-10813355-B2 Compositions for inhibition of insect sensing VANDERBILT UNIVERSITY (US) 2020-10-27 — — US disclosed
US-20190075798-A1 Compositions for Inhibition of Insect Sensing VANDERBILT UNIVERSITY 2019-03-14 — — US disclosed
US-10188105-B2 Compositions for inhibition of insect sensing VANDERBILT UNIVERSITY (US) 2019-01-29 — — US disclosed
US-9578881-B2 Compositions for inhibition of insect sensing VANDERBILT UNIVERSITY (US) 2017-02-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230136150-A1 Compositions for Inhibition of Insect Sensing OR51E2, TRPA1, OR10J3 ALDH1A1 3579/4885USP2 2348/4885RECQL 4067/4885
US-10813355-B2 Compositions for inhibition of insect sensing OR51E2, TRPA1, OR10J3 ALDH1A1 3568/4885USP2 2256/4885RECQL 3986/4885
US-20210219551-A1 Compositions for Inhibition of Insect Sensing OR51E2, TRPA1, OR10J3 ALDH1A1 3579/4885USP2 2348/4885RECQL 4067/4885
US-10188105-B2 Compositions for inhibition of insect sensing OR51E2, TRPA1, OR10J3 ALDH1A1 3533/4885USP2 2329/4885RECQL 4081/4885
US-20190075798-A1 Compositions for Inhibition of Insect Sensing OR51E2, TRPA1, OR10J3 ALDH1A1 3568/4885USP2 2256/4885RECQL 3986/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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