Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 6/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | CCR2 | P41597 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2804929 | 0.90 | BDKRB1 (0.47) | BDKRB1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL2782059 | 0.87 | BDKRB1 (0.39) | BDKRB1FAAHTRPV1CYP3A4CYP2C9 | |
| SCHEMBL185958 | 0.86 | BDKRB1 (0.44) | BDKRB1FAAHTRPV1MEN1KMT2A | |
| SCHEMBL185881 | 0.81 | OPRL1 (0.37) | BDKRB1FAAHTRPV1BTKCNR2 | |
| SCHEMBL186053 | 0.81 | CNR2 (0.34) | BDKRB1FAAHTRPV1CYP2C19RAB9A | |
| SCHEMBL186485 | 0.79 | BDKRB1 (0.32) | BDKRB1FAAHTRPV1NPC1 | |
| SCHEMBL2805808 | 0.78 | BDKRB1 (0.48) | BDKRB1MAPTNAMPTHPGD | |
| SCHEMBL185942 | 0.78 | FAAH (0.38) | BDKRB1FAAHTRPV1NAMPT | |
| SCHEMBL13128516 | 0.78 | BDKRB1 (0.48) | BDKRB1NPC1RAB9ABTKCNR2 | |
| SCHEMBL185605 | 0.78 | FAAH (0.46) | BDKRB1FAAHTRPV1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |