Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1854062 | 0.96 | NAAA (0.51) | NAAASIGMAR1STAT3TMEM97GAA | |
| SCHEMBL1858834 | 0.93 | NAAA (0.52) | NAAASIGMAR1TMEM97SMN1; SMN2HDAC3 | |
| SCHEMBL1855162 | 0.89 | NAAA (0.60) | NAAASIGMAR1TMEM97SMN1; SMN2HDAC3 | |
| SCHEMBL1854478 | 0.88 | SIGMAR1 (0.53) | NAAASIGMAR1TMEM97GAAMAPT | |
| SCHEMBL1859810 | 0.88 | NAAA (0.56) | NAAASIGMAR1STAT3TMEM97HDAC3 | |
| SCHEMBL1854504 | 0.86 | SIGMAR1 (0.49) | NAAASIGMAR1STAT3TMEM97CETP | |
| SCHEMBL1854334 | 0.86 | SIGMAR1 (0.54) | NAAASIGMAR1TMEM97GAAMAPT | |
| SCHEMBL5045478 | 0.86 | NAAA (0.54) | NAAASIGMAR1STAT3TMEM97GAA | |
| SCHEMBL1855455 | 0.86 | NAAA (0.53) | NAAASIGMAR1TMEM97SMN1; SMN2HDAC3 | |
| SCHEMBL1850770 | 0.85 | NAAA (0.52) | NAAASIGMAR1TMEM97SMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | claimed |