⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7948694 | 0.84 | — | — | |
| SCHEMBL11904391 | 0.83 | — | — | |
| SCHEMBL2407459 | 0.83 | — | — | |
| SCHEMBL1069685 | 0.81 | NLRP3 (0.31) | — | |
| SCHEMBL7262903 | 0.79 | TSHR (0.30) | — | |
| SCHEMBL7858703 | 0.79 | TSHR (0.30) | — | |
| SCHEMBL252367 | 0.79 | TSHR (0.30) | — | |
| Hydrochloric Acid SCHEMBL25380883 | 0.77 | — | — | |
| SCHEMBL3503384 | 0.76 | — | — | |
| SCHEMBL5063697 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10131908-B2 | 5′ phosphate mimics | ALNYLAM PHARMACEUTICALS, INC. (US) | 2018-11-20 | — | — | US | disclosed |
| US-20150080457-A1 | 5' PHOSPHATE MIMICS | BANK OF AMERICA, N.A. | 2015-03-19 | — | — | US | disclosed |
| US-8927513-B2 | 5′ phosphate mimics | ALNYLAM PHARMACEUTICALS, INC. (US) | 2015-01-06 | — | — | US | disclosed |
| US-20120157511-A1 | 5' PHOSPHATE MIMICS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-7943751-B2 | Ladder copolymers | NEW YORK UNIVERSITY (US) | 2011-05-17 | — | — | US | disclosed |
| US-20100081627-A1 | POLYMERIC NUCLEOSIDE PRODRUGS | RELIABLE BIOPHARMACEUTICAL, INC. (US) | 2010-04-01 | — | — | US | disclosed |
| US-20090137738-A1 | LADDER COPOLYMERS | NEW YORK UNIVERSITY (US) | 2009-05-28 | — | — | US | disclosed |
| US-7479548-B1 | Nucleic acid based ladder copolymers | NEW YORK UNIVERSITY (US) | 2009-01-20 | — | — | US | disclosed |
| US-20090005329-A1 | NUCLEIC ACID BASED LADDER COPOLYMERS | NEW YORK UNIVERSITY (US) | 2009-01-01 | — | — | US | disclosed |
| US-20070179112-A1 | POLYMERIC NUCLEOSIDE PRODRUGS | RELIABLE BIOPHARMACEUTICAL, INC. (US) | 2007-08-02 | — | — | US | disclosed |
| US-20040132684-A1 | Polymeric nucleoside prodrugs | SAMPATH UMASHANKER (US) | 2004-07-08 | — | — | US | disclosed |
| US-20020013287-A1 | Polymeric compounds useful as prodrugs | RELIABLE BIOPHARMACEUTICALS, INC. ST LOUIS MISSOURI | 2002-01-31 | — | — | US | disclosed |
| WO-2001085751-A1 | POLYMERIC COMPOUNDS USEFUL AS PRODRUGS | RELIABLE BIOPHARMACEUTICAL, INC. (US) | 2001-11-15 | — | — | WO | disclosed |
| EP-0540742-A1 | OLIGODEOXYRIBONUCLEOTIDES | Shudo, Koichi, Prof. Dr. (JP) | 1993-05-12 | — | — | EP | disclosed |
| US-5204456-A | Derivatives of nucleosides and their use for the synthesis of oligonucleotides | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1993-04-20 | — | — | US | disclosed |
| US-5179200-A | N4-(3-PHENYLPROPRIONYL)-2'-DEOXYCYTIDINE | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1993-01-12 | — | — | US | disclosed |
| US-4980460-A | Protected nucleosides which permit more efficient oligonucleotide syntheses | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1990-12-25 | — | — | US | disclosed |