⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856537 | 0.84 | — | — | |
| SCHEMBL313598 | 0.80 | TSHR (0.31) | — | |
| SCHEMBL11904391 | 0.73 | — | — | |
| SCHEMBL8817758 | 0.73 | — | — | |
| SCHEMBL7153188 | 0.70 | — | — | |
| SCHEMBL2407459 | 0.70 | — | — | |
| SCHEMBL7081474 | 0.69 | TSHR (0.30) | — | |
| SCHEMBL2522703 | 0.69 | TSHR (0.30) | — | |
| SCHEMBL1069685 | 0.69 | NLRP3 (0.31) | — | |
| SCHEMBL8143353 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262036-B1 | CHIMERIC OLIGONUCLEOSIDE COMPOUNDS USEFUL IN ACTIVATING RNASEH-MEDIATED CLEAVAGE OF TARGET RIBONUCLEIC ACID SEQUENCES, AND IN TREATING DISEASE CONDITIONS RELATING TO SUCH SEQUENCES. | GENTA INCORPORATED | 2001-07-17 | — | — | US | disclosed |
| US-6060456-A | RNASE ACTIVATING REGION; GENETIC ENGINEERING; MOLECULAR HYBRIDIZATION | GENTA INCORPORATED (US) | 2000-05-09 | — | — | US | disclosed |
| US-6028188-A | Synthetic oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages | GENTA INCORPORATED (US) | 2000-02-22 | — | — | US | disclosed |
| US-5986083-A | IDENTIFYING SINGLE STRANDED RNA TARGET SEQUENCE AND SYNTHESIZING COMPLEMENTARY OLIGOMER OF MIXED NUCLEOSIDES WITH ALTERNATING RACEMIC ARYL- OR LOWER ALKYL-PHOSPHONATE LINKAGES; HAS NUCLEASE STABILITY AND ENHANCED HYBRIDIZATION BINDING | GENTA, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5811538-A | NORMAL PHASE COLUMN CHROMATOGRAPHY ON SUPPORT COMPRISING POLYHYDROXYETHYL ASPARTAMIDE, SILICA, HYDROPHILIC SILICA | GENTA, INCORPORATED (US) | 1998-09-22 | — | — | US | disclosed |
| US-5792615-A | ANTISENSE NUCLEOTIDES PREVENTING OR INTERFERING THE GENE EXPRESSION OR TRANSLATION OF SINGLE-STRANDED RNA | GENTA, INCORPORATED (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0743859-A1 | CHIMERIC OLIGONUCLEOSIDE COMPOUNDS | GENTA INCORPORATED (US) | 1996-11-27 | — | — | EP | disclosed |