⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1069685 | 0.84 | NLRP3 (0.31) | — | |
| SCHEMBL1856537 | 0.83 | — | — | |
| SCHEMBL7858703 | 0.81 | TSHR (0.30) | — | |
| SCHEMBL252367 | 0.81 | TSHR (0.30) | — | |
| SCHEMBL7262903 | 0.81 | TSHR (0.30) | — | |
| Hydrochloric Acid SCHEMBL25380883 | 0.80 | — | — | |
| SCHEMBL8139931 | 0.80 | — | — | |
| SCHEMBL23384350 | 0.76 | TSHR (0.31) | — | |
| SCHEMBL9662674 | 0.75 | CASP1 (0.32) | — | |
| SCHEMBL5063697 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853132-B2 | Directed synthesis of oligophosphoramidate stereoisomers | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-20140045719-A1 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-8569515-B2 | Directed synthesis of oligophosphoramidate stereoisomers | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| EP-2370450-A1 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS | Roche Diagnostics GmbH (DE) | 2011-10-05 | — | — | EP | disclosed |
| US-20110212861-A1 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS | ROCHE DIAGNOSTICS GMBH (DE) | 2011-09-01 | — | — | US | disclosed |
| WO-2010060599-A1 | DIRECTED SYNTHESIS OF OLIGOPHOSPHORAMIDATE STEREOISOMERS | ROCHE DIAGNOSTICS GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |
| US-20090069263-A1 | 4'-THIOARABINONUCLEOTIDE-CONTAINING OLIGONUCLEOTIDES, COMPOUNDS AND METHODS FOR THEIR PREPARATION AND USES THEREOF | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2009-03-12 | — | — | US | disclosed |
| WO-2008141799-A1 | OLIGOPHOSPHORAMIDATES | ROCHE DIAGNOSTICS GMBH (DE) | 2008-11-27 | — | — | WO | disclosed |
| US-7427675-B2 | Compounds and methods for the characterization of oligonucleotides | ISIS PHARMACEUTICALS, INC. (US) | 2008-09-23 | — | — | US | disclosed |
| US-7427678-B2 | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method | SIGMA-ALDRICH CO. (US) | 2008-09-23 | — | — | US | disclosed |
| EP-1180113-A4 | OLIGONUCLEOTIDES HAVING A-DNA FORM AND B-DNA FORM CONFORMATIONAL GEOMETRY | ISIS PHARMACEUTICALS INC (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6369209-B1 | AFFINITY AND NUCLEASE RESISTANCE WHILE CONCURRENTLY SERVING AS SUBSTRATES FOR RNASE H WHEN BOUND TO A TARGET RNA STRAND | ISIS PHARMACEUTICALS, INC. | 2002-04-09 | — | — | US | disclosed |
| US-6365379-B1 | SELECTIVELY CLEAVING SINGLE STRANDED RNA BY CONTACTING WITH DIMERIZED ZINC FINGER PEPTIDE OF DEFINED AMINO ACID SEQUENCE IN ABSENSE OF ZINC | ISIS PHARMACEUTICALS, INC. | 2002-04-02 | — | — | US | disclosed |
| EP-1180113-A1 | OLIGONUCLEOTIDES HAVING A-DNA FORM AND B-DNA FORM CONFORMATIONAL GEOMETRY | ISIS PHARMACEUTICALS, INC. (US) | 2002-02-20 | — | — | EP | disclosed |
| WO-2001084234-A1 | METHOD FOR IMMOBILIZING OLIGONUCLEOTIDES EMPLOYING THE CYCLOADDITION BIOCONJUGATION METHOD | PROLIGO LLC (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1121455-A1 | ZINC FINGER PEPTIDE CLEAVAGE OF NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. (US) | 2001-08-08 | — | — | EP | disclosed |
| US-6271358-B1 | FOR INHIBITING SPECIFIC GENE EXPRESSION; HAVING ENHANCED HYBRID BINDING AFFINITY AND/OR INCREASED NUCLEASE RESISTANCE | ISIS PHARMACEUTICALS, INC. | 2001-08-07 | — | — | US | disclosed |
| WO-2000066609-A1 | OLIGONUCLEOTIDES HAVING A-DNA FORM AND B-DNA FORM CONFORMATIONAL GEOMETRY | ISIS PHARMACEUTICALS, INC. (US) | 2000-11-09 | — | — | WO | disclosed |
| WO-2000020622-A9 | ZINC FINGER PEPTIDE CLEAVAGE OF NUCLEIC ACIDS | ISIS PHARMACEUTICALS INC (US) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000020622-A1 | ZINC FINGER PEPTIDE CLEAVAGE OF NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. (US) | 2000-04-13 | — | — | WO | disclosed |