Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 3/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18565295 | 0.79 | BACE1 (0.43) | PSMB5TERTKDM4EKMT2AMEN1 | |
| SCHEMBL7068280 | 0.76 | TDP1 (0.55) | PSMB5KDM4ECYP1A2ALDH1A1HSD17B10 | |
| SCHEMBL27561148 | 0.69 | MAPT (0.34) | PSMB5TERTKDM4EKMT2AMEN1 | |
| SCHEMBL15983742 | 0.68 | ATM (0.42) | KDM4EKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL10390681 | 0.68 | MAPT (0.35) | PSMB5KDM4EKMT2AMEN1CYP1A2 | |
| SCHEMBL27314051 | 0.68 | KDM4E (0.55) | PSMB5TERTKDM4EKMT2AMEN1 | |
| SCHEMBL12597248 | 0.67 | CYP1A2 (0.63) | KDM4EKMT2AMEN1CYP1A2NPC1 | |
| SCHEMBL14037347 | 0.67 | TERT (0.36) | PSMB5TERTKDM4EKMT2AMEN1 | |
| SCHEMBL16641782 | 0.67 | ALDH1A1 (0.38) | KDM4EKMT2AMEN1CYP1A2ALDH1A1 | |
| SCHEMBL28247553 | 0.67 | PSMB5 (0.41) | PSMB5TERTKMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861604-B1 | MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2017-03-01 | — | — | EP | disclosed |