SCHEMBL28247553

SCHEMBL28247553

CCc1nc2cc(C)c(N(C)C)cc2cc1C

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PSMB5 P28074 2/20 0.41
TERT O14746 1/20 0.32
CRHR1 P34998 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CYP1A2 P05177 2/20 0.32
CYP3A4 P08684 2/20 0.32
POLB P06746 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
RAB9A P51151 1/20 0.32
BCAT2 O15382 1/20 0.31
CYP2D6 P10635 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16641782 0.69 ALDH1A1 (0.38) MEN1KMT2AL3MBTL1CYP1A2CYP3A4
SCHEMBL27561148 0.68 MAPT (0.34) PSMB5TERTMEN1KMT2AL3MBTL1
SCHEMBL30748201 0.67 BCAT2 (0.39) MEN1KMT2APOLBGAAMAPT
SCHEMBL7068280 0.67 TDP1 (0.55) PSMB5CYP1A2GAAMAPT
SCHEMBL27314051 0.67 KDM4E (0.55) PSMB5TERTMEN1KMT2APOLB
SCHEMBL18565488 0.67 PSMB5 (0.35) PSMB5TERTMEN1KMT2AL3MBTL1
SCHEMBL18565295 0.67 BACE1 (0.43) PSMB5TERTMEN1KMT2AL3MBTL1
SCHEMBL20620429 0.66 TERT (0.69) PSMB5TERTCRHR1MEN1KMT2A
SCHEMBL28247535 0.66 PSMB5 (0.41) PSMB5TERTCRHR1MEN1KMT2A
SCHEMBL28246786 0.65 NCF1 (0.41) MEN1KMT2ACYP1A2CYP3A4POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108690043-B Quinoline derivatives and its preparation method and application 东莞东阳光科研发有限公司 2019-10-18 CN disclosed
CN-108690043-A Quinoline derivatives and its preparation method and application 东莞东阳光科研发有限公司 2018-10-23 CN disclosed