Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185674 | 0.89 | P2RX7 (0.42) | EPHX2 | |
| SCHEMBL2810807 | 0.81 | PTGS2 (0.41) | TAS2R14ALDH1A1PTGS2EPHX2SIRT2 | |
| SCHEMBL13159675 | 0.79 | EPHX2 (0.44) | EPHX2CYP2C9 | |
| SCHEMBL19418574 | 0.79 | EPHX2 (0.44) | EPHX2CYP2C9 | |
| SCHEMBL2809264 | 0.78 | EPHX2 (0.38) | EPHX2CYP2C9SIRT2POLB | |
| SCHEMBL185134 | 0.77 | DHODH (0.45) | TAS2R14ALDH1A1EPHX2CYP2C9SIRT2 | |
| SCHEMBL2809267 | 0.77 | GAA (0.37) | ALDH1A1PTGS2EPHX2SIRT2GAA | |
| SCHEMBL2808437 | 0.77 | GAA (0.37) | ALDH1A1PTGS2EPHX2SIRT2GAA | |
| SCHEMBL2809260 | 0.77 | PTGES (0.40) | TAS2R14EPHX2SIRT2TP53 | |
| SCHEMBL185656 | 0.76 | DHODH (0.40) | ALDH1A1PTGS2SIRT2TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |