Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 11/20 | 0.42 |
| ▸ | LPL | P06858 | 10/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30015761 | 0.77 | P4HB (0.50) | P4HBLIPGLPLF11CA1 | |
| SCHEMBL488896 | 0.77 | P4HB (0.50) | P4HBLIPGLPLF11CA1 | |
| SCHEMBL20894722 | 0.77 | LIPG (0.50) | P4HBLIPGLPLIRAK4F11 | |
| SCHEMBL14760399 | 0.77 | LIPG (0.49) | P4HBLIPGLPLIRAK4F11 | |
| SCHEMBL18567448 | 0.76 | LIPG (0.41) | P4HBLIPGLPLIRAK4F11 | |
| SCHEMBL4658432 | 0.75 | L3MBTL1 (0.52) | P4HBLIPGLPL | |
| SCHEMBL30896588 | 0.75 | L3MBTL1 (0.52) | P4HBLIPGLPL | |
| SCHEMBL23031277 | 0.74 | LIPG (0.47) | P4HBLIPGLPLIRAK4F11 | |
| SCHEMBL4782167 | 0.74 | P4HB (0.47) | P4HBLIPGLPLCA1CA2 | |
| SCHEMBL1476213 | 0.74 | LIPG (0.59) | P4HBLIPGLPLIRAK4F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697210-B1 | 5-SUBSTITUTED IMINOTHIAZINES AND THEIR MONO-AND DIOXIDES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME (US) | 2017-03-01 | — | — | EP | disclosed |