Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.41 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18569502 | 0.91 | NOS2 (0.44) | KLK5MDM4MDM2HDAC1HDAC6 | |
| SCHEMBL2585645 | 0.86 | MDM4 (0.55) | KLK5MDM4MDM2ALDH1A1MEN1 | |
| SCHEMBL2585648 | 0.86 | MDM4 (0.55) | KLK5MDM4MDM2ALDH1A1MEN1 | |
| SCHEMBL16998490 | 0.83 | ALDH1A1 (0.44) | KLK5MDM4MDM2ALDH1A1LMNA | |
| SCHEMBL15565791 | 0.83 | ALDH1A1 (0.44) | KLK5MDM4MDM2ALDH1A1LMNA | |
| SCHEMBL15565793 | 0.83 | ALDH1A1 (0.44) | KLK5MDM4MDM2ALDH1A1LMNA | |
| SCHEMBL18569863 | 0.81 | KLK5 (0.44) | KLK5MDM4MDM2ALDH1A1MEN1 | |
| SCHEMBL2583014 | 0.79 | TACR1 (0.51) | KLK5ALDH1A1YAP1 | |
| SCHEMBL2583010 | 0.79 | TACR1 (0.51) | KLK5ALDH1A1YAP1 | |
| SCHEMBL2792410 | 0.79 | KLK5 (0.58) | KLK5GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882740-B1 | IAP ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-01 | — | — | EP | disclosed |