Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18570698 | 0.87 | SCN8A (0.47) | SCN8ASCN10AEPAS1KMT2AALDH1A1 | |
| SCHEMBL18570685 | 0.85 | SCN8A (0.49) | SCN8ASCN10AEPAS1GPR3SLC6A4 | |
| SCHEMBL18570617 | 0.85 | SCN8A (0.49) | SCN8ASCN10AEPAS1LMNAALDH1A1 | |
| SCHEMBL6500895 | 0.84 | GPR3 (0.42) | EPAS1LMNAGAAALDH1A1CYP1A2 | |
| SCHEMBL274702 | 0.84 | LMNA (0.52) | EPAS1LMNAGAAKMT2AALDH1A1 | |
| SCHEMBL18570714 | 0.84 | SCN10A (0.50) | SCN8ASCN10AEPAS1LMNAALDH1A1 | |
| SCHEMBL2539401 | 0.82 | CA12 (0.41) | EPAS1LMNAGAAKMT2AALDH1A1 | |
| SCHEMBL18570579 | 0.82 | L3MBTL1 (0.46) | SCN8ASCN10AEPAS1LMNAGAA | |
| SCHEMBL19563647 | 0.81 | SCN8A (0.46) | SCN8ASCN10ALMNAGAAKMT2A | |
| SCHEMBL12225949 | 0.81 | PTGDR2 (0.44) | EPAS1LMNAGAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953931-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-03-01 | — | — | EP | disclosed |