Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 11/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23892484 | 1.00 | P2RX1 (0.36) | P2RX1P2RX3P2RX4RXFP1PI4KA | |
| SCHEMBL25949205 | 0.86 | RXFP1 (0.43) | P2RX1P2RX3P2RX4RXFP1PI4KA | |
| SCHEMBL18571701 | 0.86 | RXFP1 (0.43) | P2RX1P2RX3P2RX4RXFP1PI4KA | |
| SCHEMBL18571700 | 0.85 | PI4KA (0.47) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL18571696 | 0.85 | PI4KA (0.47) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL25949203 | 0.85 | PI4KA (0.47) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL22002162 | 0.81 | PRMT5 (0.37) | RXFP1PRMT5WDR77PDPK1 | |
| SCHEMBL22002064 | 0.79 | PRMT5 (0.35) | PI4KAPI4K2BPI4K2API4KBPRMT5 | |
| SCHEMBL18571905 | 0.77 | PRMT5 (0.41) | PRMT5WDR77METTL3 | |
| SCHEMBL25046560 | 0.77 | ADK (0.41) | P2RX1P2RX3P2RX4RXFP1PI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017032840-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-02 | — | — | WO | disclosed |