Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.61 |
| ▸ | RAB9A | P51151 | 9/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | PKM | P14618 | 4/20 | 0.61 |
| ▸ | METAP2 | P50579 | 4/20 | 0.61 |
| ▸ | METAP1 | P53582 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MTOR | P42345 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29855452 | 0.82 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2PKMMETAP2 | |
| SCHEMBL19064366 | 0.82 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2PKMMETAP2 | |
| SCHEMBL11460146 | 0.81 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2PKMMETAP2 | |
| SCHEMBL20670772 | 0.78 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2PKMMETAP2 | |
| SCHEMBL5023991 | 0.77 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2PKMMETAP2 | |
| SCHEMBL1248646 | 0.77 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2PKMMETAP2 | |
| SCHEMBL13834653 | 0.76 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2PKMMETAP2 | |
| SCHEMBL124947 | 0.76 | METAP2 (1.00) | NPC1RAB9ASMN1; SMN2PKMMETAP2 | |
| SCHEMBL29405601 | 0.76 | METAP2 (1.00) | NPC1RAB9ASMN1; SMN2PKMMETAP2 | |
| SCHEMBL29484592 | 0.76 | METAP2 (1.00) | NPC1RAB9ASMN1; SMN2PKMMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11031562-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2021-06-08 | — | — | US | disclosed |
| WO-2017032439-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2017-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11031562-B2 | Metal complexes | AP1M1, SOD1, AP3M1 | NPC1 3647/4885RAB9A 2094/4885SMN1; SMN2 3771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.