Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31038425 | 1.00 | KDM4E (0.35) | KDM4EMEN1ALDH1A1TP53GAA | |
| SCHEMBL30675774 | 0.89 | PARP10 (0.41) | MEN1ALDH1A1MAPTKMT2APARP1 | |
| SCHEMBL24317405 | 0.89 | PARP10 (0.41) | MEN1ALDH1A1MAPTKMT2APARP1 | |
| SCHEMBL31731343 | 0.84 | ALDH1A1 (0.39) | KDM4EMEN1ALDH1A1TP53GAA | |
| SCHEMBL15690264 | 0.79 | UHRF1 (0.37) | KDM4EMEN1ALDH1A1TP53GAA | |
| SCHEMBL11901340 | 0.78 | PARP1 (0.44) | KDM4EMEN1ALDH1A1TP53GAA | |
| SCHEMBL10911937 | 0.78 | ALDH1A1 (0.42) | KDM4EMEN1ALDH1A1TP53GAA | |
| SCHEMBL11901695 | 0.73 | PARP1 (0.43) | KDM4EMEN1ALDH1A1TP53GAA | |
| SCHEMBL5328612 | 0.73 | PARP1 (0.39) | KDM4EMEN1ALDH1A1TP53GAA | |
| SCHEMBL844986 | 0.71 | IL1RN (0.37) | MEN1ALDH1A1MAPTHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059196-A1 | TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2025-02-20 | — | — | US | disclosed |
| WO-2024259303-A1 | COMPOUNDS AND COMPOSITIONS AS CEREBLON LIGANDS AND USES THEREOF | ONCOPIA THERAPEUTICS, INC. D/B/A SK LIFE SCIENCE LABS (US) | 2024-12-19 | — | — | WO | disclosed |
| EP-4458819-A1 | TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2024-11-06 | — | — | EP | disclosed |
| WO-2023125877-A1 | TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| EP-2917217-B1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA S A (PL) | 2017-03-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059196-A1 | TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | WEE1, CYP51A1, WEE2 | KDM4E 2363/4885MEN1 257/4885ALDH1A1 792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.