SCHEMBL185760

SCHEMBL185760

COc1cc(OC(=O)O)on1

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.39
KDM4E B2RXH2 1/20 0.39
CHRNA4 P43681 2/20 0.38
CYP1A2 P05177 1/20 0.37
TDP1 Q9NUW8 3/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 2/20 0.35
HPGD P15428 2/20 0.35
RECQL P46063 1/20 0.35
KMT2A Q03164 1/20 0.33
MME P08473 1/20 0.33
POLB P06746 2/20 0.33
HCAR2 Q8TDS4 1/20 0.32
NNMT P40261 2/20 0.31
TNFSF11 O14788 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28462799 0.81 ALOX15 (0.36) ALDH1A1KDM4ECHRNA4CYP1A2TDP1
SCHEMBL7510232 0.78 SMPD1 (0.45) ALDH1A1LMNAMAPTHPGDKMT2A
SCHEMBL3303061 0.78
SCHEMBL11144537 0.77 ALDH1A1 (0.34) ALDH1A1CHRNA4HCAR2
SCHEMBL3723489 0.77 HCAR2 (0.52) ALDH1A1KDM4ECHRNA4LMNARECQL
SCHEMBL186457 0.73 TSHR (0.32) ALDH1A1HCAR2
SCHEMBL8986681 0.73 ALDH1A1 (0.31) ALDH1A1HCAR2
SCHEMBL185759 0.73 HCAR2 (0.57) ALDH1A1KDM4ECHRNA4CYP1A2TDP1
SCHEMBL17200005 0.73 EPHX2 (0.36) ALDH1A1KDM4ETDP1KMT2AHCAR2
Hydrochloric Acid SCHEMBL2948313 0.72 HCAR2 (0.55) ALDH1A1KDM4ECHRNA4CYP1A2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2635567-B1 INDOLE DERIVATIVES RICHTER GEDEON NYRT (HU) 2015-10-28 EP claimed
EP-2401256-B1 Compounds as bradykinin B1 antagonists BOEHRINGER INGELHEIM INT (DE) 2013-04-17 EP disclosed
EP-2188254-B1 NOVEL BRADYKININ B1-ANTAGONISTS BOEHRINGER INGELHEIM INT (DE) 2012-03-21 EP disclosed
EP-2401256-A1 COMPOUNDS AS BRADYKININ B1 ANTAGONISTS Boehringer Ingelheim International GmbH (DE) 2012-01-04 EP disclosed
WO-2010097372-A1 COMPOUNDS AS BRADYKININ B1 ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-09-02 WO disclosed
WO-2010097373-A1 COMPOUNDS FOR USE AS BRADYKININ B1 ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-09-02 WO disclosed
EP-2188254-A1 NOVEL BRADYKININ B1-ANTAGONISTS Boehringer Ingelheim International GmbH (DE) 2010-05-26 EP disclosed
WO-2009027450-A1 NOVEL BRADYKININ B1-ANTAGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-03-05 WO disclosed