Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 7/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18580611 | 0.87 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2CYP1A2MAPTCYP3A4 | |
| SCHEMBL18579883 | 0.86 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2CYP1A2MAPTCYP3A4 | |
| SCHEMBL8299472 | 0.84 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2CYP1A2MAPTCYP3A4 | |
| SCHEMBL18580526 | 0.84 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2CYP1A2MAPTCYP3A4 | |
| SCHEMBL17302643 | 0.84 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2CYP1A2MAPTCYP3A4 | |
| SCHEMBL29652002 | 0.84 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2CYP1A2MAPTCYP3A4 | |
| SCHEMBL28766780 | 0.84 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2CYP1A2MAPTCYP3A4 | |
| SCHEMBL27259682 | 0.81 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CYP1A2MAPTCYP3A4 | |
| SCHEMBL9410481 | 0.81 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2CYP1A2MAPTCYP3A4 | |
| SCHEMBL28766801 | 0.81 | HTT (0.50) | ALDH1A1SMN1; SMN2CYP1A2MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11083717-B2 | Compositions and methods for drug sensitization of parasites | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2021-08-10 | — | — | US | disclosed |
| US-11083717-B2 | Compositions and methods for drug sensitization of parasites | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2021-08-10 | — | — | US | disclosed |
| EP-3659597-A2 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | The Texas A&M University System (US) | 2020-06-03 | — | — | EP | disclosed |
| US-20200138796-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | THE TEXAS A&M UNIVERSITY SYSTEM | 2020-05-07 | — | — | US | disclosed |
| US-20200138796-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | THE TEXAS A&M UNIVERSITY SYSTEM | 2020-05-07 | — | — | US | disclosed |
| US-10543200-B2 | Compositions and methods for drug sensitization of parasites | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2020-01-28 | — | — | US | disclosed |
| US-10543200-B2 | Compositions and methods for drug sensitization of parasites | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190314381-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | THE TEXAS A&M UNIVERSITY SYSTEM | 2019-10-17 | — | — | US | disclosed |
| US-20190314381-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | THE TEXAS A&M UNIVERSITY SYSTEM | 2019-10-17 | — | — | US | disclosed |
| US-10300071-B2 | Compositions and methods for inhibition of mycobacteria | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2019-05-28 | — | — | US | disclosed |
| US-10300071-B2 | Compositions and methods for inhibition of mycobacteria | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2019-05-28 | — | — | US | disclosed |
| US-20180243275-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | THE TEXAS A&M UNIVERSITY SYSTEM | 2018-08-30 | — | — | US | disclosed |
| US-20170065601-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | THE TEXAS A&M UNIVERSITY SYSTEM | 2017-03-09 | — | — | US | disclosed |
| US-20170065601-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | THE TEXAS A&M UNIVERSITY SYSTEM | 2017-03-09 | — | — | US | disclosed |
| US-20170065601-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | THE TEXAS A&M UNIVERSITY SYSTEM | 2017-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10300071-B2 | Compositions and methods for inhibition of mycobacteria | ME3, PGLS, GNPAT | ALDH1A1 1676/4885SMN1; SMN2 4812/4885CYP1A2 706/4885 |
| US-20180243275-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | ABCC1, SLC11A2, CYP3A43 | ALDH1A1 886/4885SMN1; SMN2 4303/4885CYP1A2 54/4885 |
| US-20190314381-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | ME3, PGLS, GNPAT | ALDH1A1 1676/4885SMN1; SMN2 4812/4885CYP1A2 706/4885 |
| US-20200138796-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | ABCC1, SLC11A2, ABCG2 | ALDH1A1 839/4885SMN1; SMN2 4367/4885CYP1A2 90/4885 |
| US-10543200-B2 | Compositions and methods for drug sensitization of parasites | ABCC1, SLC11A2, ABCG2 | ALDH1A1 839/4885SMN1; SMN2 4367/4885CYP1A2 90/4885 |
| US-11083717-B2 | Compositions and methods for drug sensitization of parasites | ABCC1, SLC11A2, ABCG2 | ALDH1A1 839/4885SMN1; SMN2 4367/4885CYP1A2 90/4885 |
| US-20170065601-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA | ME3, PGLS, GNPAT | ALDH1A1 1676/4885SMN1; SMN2 4812/4885CYP1A2 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.