Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.31 |
| ▸ | PEPD | P12955 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27826679 | 0.87 | — | — | |
| Oxalic Acid SCHEMBL18628689 | 0.83 | MEN1 (0.37) | CA2CA1CA9MEN1LMNA | |
| Oxalic Acid SCHEMBL28952629 | 0.83 | MEN1 (0.37) | CA2CA1CA9MEN1LMNA | |
| Phosphoric Acid SCHEMBL28048398 | 0.82 | CA2 (0.50) | CA2CA1CA9MEN1LMNA | |
| Phosphoric Acid SCHEMBL6112781 | 0.82 | CA2 (0.50) | CA2CA1CA9MEN1LMNA | |
| Phosphoric Acid SCHEMBL28318521 | 0.82 | CA2 (0.50) | CA2CA1CA9MEN1LMNA | |
| Phosphoric Acid SCHEMBL9449859 | 0.82 | CA2 (0.50) | CA2CA1CA9MEN1LMNA | |
| Phosphoric Acid SCHEMBL6112776 | 0.82 | CA2 (0.50) | CA2CA1CA9MEN1LMNA | |
| Phosphoric Acid SCHEMBL345048 | 0.82 | CA2 (0.50) | CA2CA1CA9MEN1LMNA | |
| Phosphoric Acid SCHEMBL285675 | 0.82 | CA2 (0.50) | CA2CA1CA9MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9668844-B2 | Device for fixation at a dental site | COLLDENT Y.A LTD (IL) | 2017-06-06 | — | — | US | disclosed |
| US-20150125810-A1 | DEVICE FOR FIXATION AT A DENTAL SITE | COLLDENT Y.A. LTD. (IL) | 2015-05-07 | — | — | US | disclosed |
| US-20130108982-A1 | Reshapable Device for Fixation at a Dental Site | COLLDENT Y.A. LTD. (IL) | 2013-05-02 | — | — | US | disclosed |
| US-8287277-B2 | Reshapable device for fixation at a dental site | Colldent V.A. Ltd. (IL) | 2012-10-16 | — | — | US | disclosed |
| US-20110104635-A1 | RESHAPABLE DEVICE FOR FIXATION AT A DENTAL SITE | COLL PARTNERS LTD. (VG) | 2011-05-05 | — | — | US | disclosed |
| US-7850453-B2 | Reshapable device for fixation at a dental site | COLL PARTNERS LTD. (VG) | 2010-12-14 | — | — | US | disclosed |
| EP-2185099-A1 | RESHAPABLE DEVICE FOR FIXATION AT A DENTAL SITE | Coll Partners Ltd. (VG) | 2010-05-19 | — | — | EP | disclosed |
| US-20090042161-A1 | Reshapable device for fixation at a dental site | COLLDENT Y.A. LTD. (IL) | 2009-02-12 | — | — | US | disclosed |
| WO-2009019697-A1 | RESHAPABLE DEVICE FOR FIXATION AT A DENTAL SITE | COLL PARTNERS LTD. (VG) | 2009-02-12 | — | — | WO | disclosed |
| EP-1098623-A2 | ODONTOSTOMATOLOGIC USE OF APATITE-BASED NANOSTRUCTURED MATERIALS | Dolci, Giovanni (IT) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000003747-A2 | ODONTOSTOMATOLOGIC USE OF APATITE-BASED NANOSTRUCTURED MATERIALS | DOLCI GIOVANNI (IT) | 2000-01-27 | — | — | WO | disclosed |