Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TSPO | P30536 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24093939 | 0.85 | MEN1 (0.44) | MEN1KMT2AOPRM1OPRL1CCR2 | |
| SCHEMBL18171825 | 0.81 | GRM2 (0.51) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL18555694 | 0.74 | PRMT5 (0.46) | MEN1KMT2ACCR2PRMT5WDR77 | |
| SCHEMBL2762363 | 0.74 | ALDH1A1 (0.54) | MEN1KMT2AALDH1A1KDM4ETSHR | |
| SCHEMBL18171783 | 0.72 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL18555697 | 0.70 | PTGS2 (0.52) | MEN1KMT2ACCR2PDE1B | |
| SCHEMBL18171826 | 0.70 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL11263773 | 0.70 | MEN1 (0.72) | MEN1KMT2AALDH1A1KDM4ETSHR | |
| SCHEMBL32674290 | 0.69 | MIF (0.56) | MEN1KMT2AALDH1A1KDM4ETSHR | |
| SCHEMBL11257792 | 0.69 | MEN1 (0.64) | MEN1KMT2AMAPTHDAC1HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017035415-A1 | ALKYNE COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS | ACHILLION PHARMACEUTICALS, INC. (US) | 2017-03-02 | — | — | WO | disclosed |