Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.43 |
| ▸ | MEN1 | O00255 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.31 |
| ▸ | CA1 | P00915 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17595117 | 0.85 | MAPT (0.51) | MAPTMEN1KMT2AMAPK1GAA | |
| SCHEMBL17595119 | 0.85 | MAPT (0.51) | MAPTMEN1KMT2AMAPK1GAA | |
| SCHEMBL17594881 | 0.77 | — | — | |
| SCHEMBL18584768 | 0.76 | MEN1 (0.45) | MAPTMEN1KMT2AMAPK1GAA | |
| SCHEMBL17595330 | 0.72 | MAPT (0.54) | MAPTMEN1KMT2AMAPK1GAA | |
| SCHEMBL17595329 | 0.72 | MAPT (0.54) | MAPTMEN1KMT2AMAPK1GAA | |
| SCHEMBL18621539 | 0.72 | TDP1 (0.51) | MAPTMEN1KMT2AMAPK1GAA | |
| SCHEMBL18620549 | 0.66 | MAPT (0.51) | MAPTMEN1KMT2AMAPK1GAA | |
| SCHEMBL17595861 | 0.65 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL28292454 | 0.65 | MAPT (0.47) | MAPTMEN1KMT2AMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040449-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-09 | — | — | WO | disclosed |