SCHEMBL18588463

SCHEMBL18588463

CC(=O)[C@H]1CCCC[C@H]1C(=O)NCCN

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.42
GRM4 Q14833 1/20 0.41
CTSB P07858 3/20 0.41
CTSS P25774 3/20 0.41
CTSK P43235 3/20 0.41
HSD17B10 Q99714 2/20 0.39
ALDH1A1 P00352 1/20 0.39
CASP1 P29466 1/20 0.39
PSEN1 P49768 1/20 0.39
PSEN2 P49810 1/20 0.39
APH1B Q8WW43 1/20 0.39
NCSTN Q92542 1/20 0.39
APH1A Q96BI3 1/20 0.39
PSENEN Q9NZ42 1/20 0.39
MC4R P32245 1/20 0.38
NAAA Q02083 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17970596 1.00 TAAR1 (0.42) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL13818150 0.91 TAAR1 (0.47) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL4824953 0.84 GRM4 (0.44) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL4598374 0.84 GRM4 (0.44) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL14159195 0.84 TAAR1 (0.58) TAAR1HSD17B10ALDH1A1CASP1MC4R
SCHEMBL26506434 0.83 GRM4 (0.43) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL25139931 0.81 TAAR1 (0.39) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL18735699 0.81 TAAR1 (0.39) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL21883928 0.81 TAAR1 (0.40) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL21883953 0.81 TAAR1 (0.39) TAAR1GRM4CTSBCTSSCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220118055-A1 RELEASABLE GLP-1 CONJUGATES FISH & RICHARDSON PC 2022-04-21 US disclosed
EP-2237799-B1 PRODRUG COMPRISING A SELF-CLEAVABLE LINKER ASCENDIS PHARMA AS (DK) 2019-04-10 EP disclosed
US-9919033-B2 Dry growth hormone composition transiently linked to a polymer carrier ASCENDIS PHARMA ENDOCRINOLOGY DIVISION A/S (DK) 2018-03-20 US disclosed
US-20170056477-A1 Dry Growth Hormone Composition Transiently Linked to a Polymer Carrier ASCENDIS PHARMA GROWTH DISORDERS DIVISION A/S (DK) 2017-03-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170056477-A1 Dry Growth Hormone Composition Transiently Linked to a Polymer Carrier GHRHR, GHSR, GCG TAAR1 3316/4885GRM4 3066/4885CTSB 846/4885
US-20220118055-A1 RELEASABLE GLP-1 CONJUGATES GLP1R, GIPR, IAPP TAAR1 2682/4885GRM4 2623/4885CTSB 1315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.