SCHEMBL21883928

SCHEMBL21883928

CC(C)C(=O)[C@H]1CCCC[C@H]1C(=O)NCCN

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 4/20 0.40
GRM4 Q14833 1/20 0.39
CTSB P07858 2/20 0.38
CTSS P25774 2/20 0.38
CTSK P43235 2/20 0.38
HSD17B10 Q99714 2/20 0.37
ALDH1A1 P00352 1/20 0.37
CASP1 P29466 1/20 0.37
MC4R P32245 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13818150 0.86 TAAR1 (0.47) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL17970596 0.81 TAAR1 (0.42) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL18588463 0.81 TAAR1 (0.42) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL21716647 0.81 L3MBTL1 (0.45) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL4824953 0.80 GRM4 (0.44) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL14159195 0.80 TAAR1 (0.58) TAAR1HSD17B10ALDH1A1CASP1MC4R
SCHEMBL4598374 0.80 GRM4 (0.44) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL24904183 0.79 LMNA (0.42) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL22415478 0.79 KMT2A (0.54) TAAR1GRM4CTSBCTSSCTSK
SCHEMBL21347705 0.79 SIGMAR1 (0.47) CTSBCTSSCTSKALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4011396-A1 RELEASABLE CONJUGATES QuiaPEG Pharmaceuticals AB (SE) 2022-06-15 EP disclosed
US-11357828-B2 Releasable GLP-1 conjugates QUIAPEG PHARMACEUTICALS AB (SE) 2022-06-14 US disclosed
US-20220118055-A1 RELEASABLE GLP-1 CONJUGATES FISH & RICHARDSON PC 2022-04-21 US disclosed
US-20210170045-A1 RELEASABLE ANTIBODY CONJUGATES FISH & RICHARDSON PC 2021-06-10 US disclosed
WO-2020053815-A1 RELEASABLE GLP-1 CONJUGATES QUIAPEG PHARMACEUTICALS AB (SE) 2020-03-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210170045-A1 RELEASABLE ANTIBODY CONJUGATES BCR, CD47, RNASE1 TAAR1 4785/4885GRM4 4777/4885CTSB 252/4885
US-11357828-B2 Releasable GLP-1 conjugates GLP1R, GIPR, IAPP TAAR1 2682/4885GRM4 2623/4885CTSB 1315/4885
US-20220118055-A1 RELEASABLE GLP-1 CONJUGATES GLP1R, GIPR, IAPP TAAR1 2682/4885GRM4 2623/4885CTSB 1315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.