Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 5/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186210 | 0.92 | POLB (0.34) | CNR2ARLMNA | |
| SCHEMBL185974 | 0.90 | CTDSP1 (0.34) | BDKRB1FAAH | |
| SCHEMBL2805738 | 0.89 | AR (0.39) | OPRL1CNR2ARALDH1A1LMNA | |
| SCHEMBL185881 | 0.88 | OPRL1 (0.37) | OPRL1CNR2ALDH1A1LMNABDKRB1 | |
| SCHEMBL185483 | 0.85 | OPRL1 (0.38) | OPRL1CNR2ALDH1A1LMNABDKRB1 | |
| SCHEMBL186511 | 0.84 | OPRL1 (0.39) | OPRL1CNR2VNN1FAAHHDAC1 | |
| SCHEMBL185517 | 0.84 | OPRL1 (0.37) | OPRL1CNR2BDKRB1FAAH | |
| SCHEMBL186275 | 0.84 | BTK (0.38) | OPRL1CNR2VNN1BDKRB1FAAH | |
| SCHEMBL16266044 | 0.83 | OPRL1 (0.35) | OPRL1CNR2ALDH1A1LMNAFAAH | |
| SCHEMBL199266 | 0.83 | OPRL1 (0.36) | OPRL1CNR2BDKRB1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |