SCHEMBL1858994

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1858885	0.92	SMN1; SMN2 (0.43)	TSHRSMN1; SMN2LMNACYP1A2NPC1
	SCHEMBL1862331	0.90	WDR91 (0.39)	SMN1; SMN2NPC1RAB9AALDH1A1KMT2A
	SCHEMBL1863141	0.90	HSD17B10 (0.40)	SMN1; SMN2LMNACYP1A2CYP2D6NPC1
	SCHEMBL1858923	0.89	HDAC1 (0.38)	TSHRSMN1; SMN2LMNACYP1A2CYP2D6
	SCHEMBL1860090	0.89	CYP1A2 (0.36)	SMN1; SMN2CYP1A2NPC1RAB9AALDH1A1
	SCHEMBL1867281	0.88	ALDH1A1 (0.42)	NPC1RAB9AALDH1A1HTT
	SCHEMBL1860644	0.88	LMNA (0.39)	LMNA
	SCHEMBL1855402	0.87	SMN1; SMN2 (0.38)	SMN1; SMN2LMNARAB9AALDH1A1KMT2A
	SCHEMBL1863968	0.86	SMN1; SMN2 (0.52)	TSHRSMN1; SMN2LMNAKMT2AMEN1
	SCHEMBL1860843	0.86	PPARA (0.46)	SMN1; SMN2CYP1A2RAB9AKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.