Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18856317 | 0.98 | FAAH (0.46) | FAAHLMNATRPV1ACE2CNR1 | |
| SCHEMBL9550648 | 0.83 | TRPV1 (0.54) | FAAHLMNATRPV1ACE2CNR1 | |
| SCHEMBL18595203 | 0.83 | FAAH (0.46) | FAAHLMNAACE2CNR1CNR2 | |
| SCHEMBL19333632 | 0.81 | LMNA (0.50) | FAAHLMNAACE2CNR1CNR2 | |
| SCHEMBL18558918 | 0.81 | ZDHHC7 (0.47) | FAAHLMNAACE2CNR1CNR2 | |
| SCHEMBL17995985 | 0.81 | LMNA (0.65) | LMNAPRKCAMAPT | |
| SCHEMBL18595316 | 0.81 | LMNA (0.50) | FAAHLMNAACE2CNR1CNR2 | |
| SCHEMBL30870109 | 0.81 | TRPV1 (0.51) | FAAHLMNATRPV1ACE2CNR1 | |
| SCHEMBL18595264 | 0.80 | FAAH (0.44) | FAAHLMNAACE2CNR1CNR2 | |
| SCHEMBL20260562 | 0.80 | FAAH (0.41) | FAAHLMNAACE2CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |