Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18595178 | 1.00 | LMNA (0.47) | LMNAUSP2HTTGPR84FFAR1 | |
| SCHEMBL4608903 | 0.84 | GPR84 (0.50) | LMNAUSP2HTTGPR84FFAR1 | |
| SCHEMBL28182394 | 0.84 | GPR84 (0.50) | LMNAUSP2HTTGPR84FFAR1 | |
| SCHEMBL4608661 | 0.84 | GPR84 (0.50) | LMNAUSP2HTTGPR84FFAR1 | |
| SCHEMBL965066 | 0.84 | GPR84 (0.50) | LMNAUSP2HTTGPR84FFAR1 | |
| SCHEMBL4406662 | 0.84 | GPR84 (0.50) | LMNAUSP2HTTGPR84FFAR1 | |
| SCHEMBL4610388 | 0.84 | GPR84 (0.50) | LMNAUSP2HTTGPR84FFAR1 | |
| SCHEMBL16418383 | 0.83 | LMNA (0.58) | LMNAHTTGPR84FFAR1FFAR4 | |
| SCHEMBL19236247 | 0.83 | LMNA (0.45) | LMNAUSP2HTTGPR84FFAR1 | |
| SCHEMBL4604693 | 0.81 | LMNA (0.56) | LMNAHTTGPR84FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |