Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12376659 | 0.82 | MAPT (0.48) | MAPTMEN1KMT2AMAOAMAOB | |
| SCHEMBL20344700 | 0.81 | MET (0.41) | MEN1KMT2AMAOAMAOBMET | |
| SCHEMBL11633601 | 0.80 | ALDH1A1 (0.46) | METSMN1; SMN2KDM4EPOLBAPEX1 | |
| SCHEMBL22210774 | 0.79 | ALDH1A1 (0.47) | MAPTKMT2AMETSMN1; SMN2KDM4E | |
| SCHEMBL12376649 | 0.77 | MAPT (0.47) | MAPTMEN1KMT2AMAOAMAOB | |
| SCHEMBL22210780 | 0.77 | NPC1 (0.58) | MAPTMEN1KMT2AMETSMN1; SMN2 | |
| SCHEMBL18596536 | 0.75 | MAPT (0.42) | MAPTMEN1KMT2AMAOAMAOB | |
| SCHEMBL6748722 | 0.74 | MAPT (0.61) | MAPTMEN1KMT2AMAOAMAOB | |
| SCHEMBL13101588 | 0.74 | BRD4 (0.73) | MAPTMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL12376654 | 0.74 | MET (0.50) | MEN1KMT2AMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208034-B2 | Quinoline derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2019-02-19 | — | — | US | disclosed |
| US-20170349583-A1 | QUINOLINE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-12-07 | — | — | US | disclosed |
| US-9586967-B2 | Pyrrolo pyrimidine derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349583-A1 | QUINOLINE DERIVATIVE | FLT3, AXL, ABL1 | MAPT 2114/4885MEN1 441/4885KMT2A 369/4885 |
| US-10208034-B2 | Quinoline derivative | FLT3, AXL, ABL1 | MAPT 2114/4885MEN1 441/4885KMT2A 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.