Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | RECQL | P46063 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | APP | P05067 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.57 |
| ▸ | ELAVL3 | Q14576 | 2/20 | 0.57 |
| ▸ | IPMK | Q8NFU5 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.57 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.56 |
| ▸ | PLG | P00747 | 1/20 | 0.56 |
| ▸ | POLH | Q9Y253 | 7/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22449722 | 0.84 | POLH (0.71) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL28041625 | 0.77 | POLH (0.76) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL27772072 | 0.77 | ABCB1 (0.76) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL19756750 | 0.74 | POLH (0.61) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL19943189 | 0.74 | CYP3A4 (0.70) | MEN1KMT2AMAPTKDM4ERECQL | |
| Rhamnetin SCHEMBL29453025 | 0.73 | MEN1 (1.00) | MEN1KMT2AMAPTKDM4ERECQL | |
| Rhamnetin SCHEMBL29496169 | 0.73 | MEN1 (1.00) | MEN1KMT2AMAPTKDM4ERECQL | |
| Rhamnetin SCHEMBL555118 | 0.73 | MEN1 (1.00) | MEN1KMT2AMAPTKDM4ERECQL | |
| Rhamnetin SCHEMBL7164573 | 0.73 | MEN1 (1.00) | MEN1KMT2AMAPTKDM4ERECQL | |
| SCHEMBL21621459 | 0.73 | ADORA3 (0.61) | MEN1KMT2AMAPTKDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138838-A1 | SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS | Dana-Farber Cancer Institute, Inc. (US) | 2017-03-08 | — | — | EP | disclosed |