Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14680529 | 0.86 | ALDH1A1 (0.63) | MAPTALDH1A1KDM4ERXFP1HPGD | |
| SCHEMBL20272284 | 0.71 | MAPT (0.48) | MAPTALDH1A1KDM4EPOLBRXFP1 | |
| SCHEMBL8289404 | 0.70 | ALDH1A1 (0.80) | MAPTALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL31277120 | 0.67 | ALDH1A1 (0.55) | MAPTALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL4080979 | 0.66 | ALDH1A1 (0.60) | MAPTALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL3767865 | 0.66 | MAPK1 (0.66) | MAPTALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL7825608 | 0.65 | ALDH1A1 (0.61) | MAPTALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL21603842 | 0.63 | CXCR2 (0.61) | MAPTALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL12903924 | 0.63 | MAPT (0.60) | MAPTALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL2644504 | 0.63 | ALDH1A1 (0.97) | MAPTALDH1A1KDM4ELMNARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138838-A1 | SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS | Dana-Farber Cancer Institute, Inc. (US) | 2017-03-08 | — | — | EP | disclosed |