Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.83 |
| ▸ | MEN1 | O00255 | 11/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.83 |
| ▸ | POLB | P06746 | 10/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.83 |
| ▸ | RECQL | P46063 | 9/20 | 0.83 |
| ▸ | USP2 | O75604 | 8/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.83 |
| ▸ | BLM | P54132 | 6/20 | 0.83 |
| ▸ | THRB | P10828 | 5/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.83 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.83 |
| ▸ | MMP2 | P08253 | 1/20 | 0.83 |
| ▸ | ALPL | P05186 | 4/20 | 0.68 |
| ▸ | NSD2 | O96028 | 3/20 | 0.68 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.68 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.68 |
| ▸ | APAF1 | O14727 | 1/20 | 0.68 |
| ▸ | APEX1 | P27695 | 6/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14680220 | 0.91 | MAPT (1.00) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL26458902 | 0.91 | MAPT (1.00) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL14680251 | 0.79 | MAPT (0.78) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL14680229 | 0.76 | MAPT (1.00) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL5991599 | 0.75 | MEN1 (0.75) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL19419942 | 0.73 | MAPT (0.83) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL20705581 | 0.72 | MAPT (0.67) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL6886015 | 0.72 | MAPT (0.88) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL19425501 | 0.70 | DUSP3 (0.72) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL26485785 | 0.70 | MAPT (0.65) | MAPTMEN1KMT2APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138838-A1 | SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATING DISORDERS | Dana-Farber Cancer Institute, Inc. (US) | 2017-03-08 | — | — | EP | disclosed |