Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.83 |
| ▸ | MEN1 | O00255 | 13/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.83 |
| ▸ | POLB | P06746 | 12/20 | 0.83 |
| ▸ | USP2 | O75604 | 10/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.83 |
| ▸ | RECQL | P46063 | 9/20 | 0.83 |
| ▸ | BLM | P54132 | 7/20 | 0.83 |
| ▸ | APEX1 | P27695 | 6/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.83 |
| ▸ | THRB | P10828 | 5/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.83 |
| ▸ | HPGD | P15428 | 2/20 | 0.83 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.83 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.83 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.83 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14680229 | 0.91 | MAPT (1.00) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL26485785 | 0.77 | MAPT (0.65) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL26458902 | 0.76 | MAPT (1.00) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL14680220 | 0.76 | MAPT (1.00) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL13852445 | 0.74 | MAPT (0.72) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL4143167 | 0.74 | MAPT (0.72) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL17833967 | 0.73 | MAPT (0.67) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL18598496 | 0.73 | MAPT (0.83) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL6886015 | 0.72 | MAPT (0.88) | MAPTMEN1KMT2APOLBUSP2 | |
| SCHEMBL5991599 | 0.71 | MEN1 (0.75) | MAPTMEN1KMT2APOLBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | MAPT 1762/4885MEN1 3416/4885KMT2A 3471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.