Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 11/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1715359 | 0.95 | CYP1A2 (0.46) | GAACYP1A2ALDH1A1POLBPDE4A | |
| SCHEMBL30184869 | 0.95 | CYP1A2 (0.46) | GAACYP1A2ALDH1A1POLBPDE4A | |
| SCHEMBL3404994 | 0.80 | CYP1A2 (0.49) | GAACYP1A2ALDH1A1POLBPDE4A | |
| SCHEMBL3410556 | 0.78 | CYP1A2 (0.50) | GAACYP1A2ALDH1A1POLBPDE4A | |
| SCHEMBL6045501 | 0.76 | SMN1; SMN2 (0.53) | ALDH1A1POLB | |
| SCHEMBL11428637 | 0.75 | P2RX7 (0.47) | POLBMAPTP2RX7 | |
| SCHEMBL2534556 | 0.75 | CYP1A2 (0.70) | GAACYP1A2ALDH1A1POLBPDE4A | |
| SCHEMBL12456440 | 0.75 | CYP1A2 (0.46) | GAACYP1A2ALDH1A1POLBPDE4A | |
| SCHEMBL12456043 | 0.75 | CYP1A2 (0.46) | GAACYP1A2ALDH1A1POLBPDE4A | |
| SCHEMBL8582756 | 0.74 | P2RX7 (0.50) | GAAALDH1A1POLBMAPTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401260-A1 | DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097465-A1 | DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-09-02 | — | — | WO | disclosed |