Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21507537 | 0.72 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1BCDIN3DCNR1CNR2 | |
| SCHEMBL587580 | 0.71 | DRD2 (0.36) | SMN1; SMN2TNFGRM4DRD2DRD3 | |
| SCHEMBL16955156 | 0.66 | ENPP2 (0.40) | TNFGRM4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL29013128 | 0.65 | GRM4 (0.44) | ADRA2CTNFGRM4BCDIN3DS1PR1 | |
| Ethylene SCHEMBL7173481 | 0.64 | GRM4 (0.43) | ALDH1A1TNFGRM4GRIN2DGRIN3B | |
| SCHEMBL6163795 | 0.64 | ENPP2 (0.46) | ALDH1A1MAPTTNFGRM4GRIN2D | |
| SCHEMBL2939744 | 0.63 | GRM4 (0.44) | ALDH1A1TNFGRM4GRIN2DGRIN3B | |
| SCHEMBL3882898 | 0.63 | GSK3B (0.50) | ALDH1A1MAPTTNFGRM4DRD2 | |
| SCHEMBL4083138 | 0.63 | ENPP2 (0.47) | ALDH1A1MAPTTNFGRM4DRD2 | |
| SCHEMBL16951467 | 0.62 | ENPP2 (0.39) | TNFGRM4CNR1CNR2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348023-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |