Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12330461 | 0.85 | PDE4A (0.38) | SGMS2ALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL9921700 | 0.81 | KDM4E (0.37) | SGMS2ALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL9918378 | 0.79 | KMT2A (0.45) | SGMS2ALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL171764 | 0.79 | SGMS2 (0.34) | SGMS2ALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL11082488 | 0.78 | ALDH1A1 (0.44) | SGMS2ALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL11078305 | 0.74 | NPSR1 (0.47) | SGMS2ALDH1A1LMNAKMT2AL3MBTL1 | |
| SCHEMBL11085344 | 0.74 | CYP1A2 (0.38) | SGMS2ALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL31391963 | 0.73 | ALOX5AP (0.39) | SGMS2ALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL9918828 | 0.72 | BRPF1 (0.32) | SGMS2ALDH1A1LMNACYP1A2CYP2C9 | |
| SCHEMBL11082428 | 0.71 | SGMS2 (0.57) | SGMS2ALDH1A1LMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348023-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |