Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318826 | 0.91 | DRD2 (0.62) | DRD2DRD4HTR2ADRD3HTR7 | |
| SCHEMBL319163 | 0.81 | OPRM1 (0.51) | GRM2OPRL1OPRM1CYP2D6TP53 | |
| SCHEMBL318743 | 0.80 | DRD2 (0.65) | DRD2DRD4HTR2ADRD3HTR7 | |
| SCHEMBL320115 | 0.80 | OPRK1 (0.50) | OPRL1OPRM1OPRD1OPRK1MEN1 | |
| SCHEMBL318732 | 0.77 | MEN1 (0.53) | HTR7MEN1CYP3A4CYP2D6KMT2A | |
| SCHEMBL318729 | 0.76 | MEN1 (0.54) | OPRL1MEN1CYP3A4CYP2D6KMT2A | |
| SCHEMBL318896 | 0.75 | MEN1 (0.53) | HTR7OPRL1MEN1CYP3A4CYP2D6 | |
| SCHEMBL318926 | 0.74 | MEN1 (0.52) | HTR7MEN1CYP3A4CYP2D6KMT2A | |
| SCHEMBL319008 | 0.74 | MEN1 (0.81) | DRD2DRD4HTR2ADRD3MEN1 | |
| SCHEMBL7760221 | 0.73 | MEN1 (0.75) | DRD2DRD3OPRL1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138841-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2017-03-08 | — | — | EP | disclosed |