Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.55 |
| ▸ | TAS1R2 | Q8TE23 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | SPR | P35270 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18608347 | 0.81 | TAS1R3 (0.57) | LMNATAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL18608561 | 0.81 | ALDH1A1 (0.53) | LMNAKDM4EALDH1A1GAAPKM | |
| SCHEMBL9130281 | 0.80 | ALDH1A1 (0.62) | KDM4EALDH1A1GAAPKMMAPT | |
| SCHEMBL18608724 | 0.79 | ALDH1A1 (0.56) | LMNATAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL18608551 | 0.75 | PDE2A (0.55) | LMNATAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL20337349 | 0.75 | ALDH1A1 (0.58) | LMNATAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL17743122 | 0.75 | ALDH1A1 (0.58) | LMNATAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL19555629 | 0.74 | KDM4E (0.59) | LMNATAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL19579149 | 0.74 | KDM4E (0.59) | LMNATAS1R3TAS1R1TAS1R2KDM4E | |
| SCHEMBL18608253 | 0.74 | ALDH1A1 (0.62) | LMNATAS1R3TAS1R1TAS1R2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190112316-A1 | THIAZOLO[3,2-A] PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY | LYSOSOMAL THERAPEUTICS INC (US) | 2019-04-18 | — | — | US | disclosed |
| WO-2017040879-A1 | THIAZOLO(3,2-A) PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY | LYSOSOMAL THERAPEUTICS INC. (US) | 2017-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190112316-A1 | THIAZOLO[3,2-A] PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY | PARK7, GAA, TYMP | LMNA 1702/4885TAS1R3 953/4885TAS1R1 926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.