Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.40 |
| ▸ | FAP | Q12884 | 2/20 | 0.40 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1630456 | 0.89 | SMYD3 (0.37) | ITGB3ITGA2B | |
| SCHEMBL1631028 | 0.89 | DPP4 (0.42) | DPP4DPP8DPP9FAPPREP | |
| SCHEMBL1632874 | 0.84 | POLB (0.39) | DPP4DPP8DPP9FAPPREP | |
| SCHEMBL1631839 | 0.82 | DPP4 (0.58) | DPP4DPP8DPP9FAPPREP | |
| SCHEMBL8304001 | 0.82 | DPP4 (0.58) | DPP4DPP8DPP9FAPPREP | |
| SCHEMBL1860910 | 0.79 | SMYD3 (0.43) | DPP4DPP8DPP9FAPPREP | |
| SCHEMBL7656406 | 0.78 | DPP4 (0.55) | DPP4ACE | |
| Hydrochloric Acid SCHEMBL10963697 | 0.77 | ACE (0.63) | DPP4ACESPHK1 | |
| SCHEMBL770741 | 0.77 | DPP7 (0.46) | DPP4DPP8DPP9FAPPREP | |
| SCHEMBL16935720 | 0.77 | DPP4 (0.51) | DPP4DPP8DPP9FAPPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939534-B2 | e.g. (2-{[2-(3-fluorophenyl)ethyl]amino}-6-piperidyl(3-pyridyl))-N-(3-pyridylmethyl)carboxamide; smooth muscle myosin or non-muscle myosin modulator; hypotensive agent; asthma, chronic obstructive pulmonary disease, bronchoconstrictive disease, glaucoma, pre-menstrual cramps, erectile dysfunction | CYTOKINETICS, INC. (US) | 2011-05-10 | — | — | US | claimed |