Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 1/20 | 0.67 |
| ▸ | MPO | P05164 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | CASP6 | P55212 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | NT5E | P21589 | 1/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18726066 | 1.00 | MMP9 (0.67) | MMP9MPOGAAMAPTRAB9A | |
| SCHEMBL19936630 | 0.87 | MAPT (0.70) | MPOGAAMAPTRAB9AKDM4E | |
| SCHEMBL18609202 | 0.83 | MMP9 (0.62) | MMP9MPOGAAMAPTRAB9A | |
| SCHEMBL18740661 | 0.83 | MMP9 (0.62) | MMP9MPOGAAMAPTRAB9A | |
| SCHEMBL16224335 | 0.83 | MMP9 (0.70) | MMP9MPOGAAMAPTRAB9A | |
| SCHEMBL18726040 | 0.83 | GAA (0.64) | MMP9MPOGAAMAPTRAB9A | |
| SCHEMBL17073225 | 0.83 | GAA (0.64) | MMP9MPOGAAMAPTRAB9A | |
| SCHEMBL591866 | 0.82 | MAPT (0.73) | MMP9MPOGAAMAPTRAB9A | |
| SCHEMBL31021335 | 0.82 | MAPT (0.73) | MMP9MPOGAAMAPTRAB9A | |
| Hydrochloric Acid SCHEMBL17561015 | 0.81 | MMP9 (0.68) | MMP9MPOGAAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3362448-B1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | INVENTIVA (FR) | 2021-08-04 | — | — | EP | disclosed |
| EP-3362448-B1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | INVENTIVA (FR) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020150423-A1 | METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | YUMANITY THERAPEUTICS, INC. (US) | 2020-07-23 | — | — | WO | disclosed |
| US-10414739-B2 | Compounds as inhibitors of the YAP/TAZ-TEAD interaction and their use in the treatment of malignant mesothelioma | INVENTIVA (FR) | 2019-09-17 | — | — | US | disclosed |
| US-10414739-B2 | Compounds as inhibitors of the YAP/TAZ-TEAD interaction and their use in the treatment of malignant mesothelioma | INVENTIVA (FR) | 2019-09-17 | — | — | US | disclosed |
| US-20180297964-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | INVENTIVA (FR) | 2018-10-18 | — | — | US | disclosed |
| EP-3362448-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | Inventiva (FR) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017064277-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | INVENTIVA (FR) | 2017-04-20 | — | — | WO | disclosed |
| WO-2017064277-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | INVENTIVA (FR) | 2017-04-20 | — | — | WO | disclosed |
| EP-3156404-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | INVENTIVA (FR) | 2017-04-19 | — | — | EP | disclosed |
| EP-3156404-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | INVENTIVA (FR) | 2017-04-19 | — | — | EP | disclosed |
| US-20170066731-A1 | SMALL MOLECULE FATTY ACID SYNTHASE INHIBITORS | Sanford Burnham Prebys Medical Discovery Institute | 2017-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180297964-A1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | YAP1, TEAD2, TEAD1 | MMP9 1949/4885MPO 4315/4885GAA 4858/4885 |
| US-10414739-B2 | Compounds as inhibitors of the YAP/TAZ-TEAD interaction and their use in the treatment of malignant mesothelioma | YAP1, TEAD2, TEAD1 | MMP9 1632/4885MPO 4060/4885GAA 4852/4885 |
| US-20170066731-A1 | SMALL MOLECULE FATTY ACID SYNTHASE INHIBITORS | FASN, FADS2, FADS1 | MMP9 1772/4885MPO 2383/4885GAA 485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.