Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 3/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.50 |
| ▸ | GRK2 | P25098 | 2/20 | 0.50 |
| ▸ | GRK1 | Q15835 | 2/20 | 0.50 |
| ▸ | GRK5 | P34947 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3847802 | 0.86 | ATM (0.45) | ATMGRK2GRK1GRK5 | |
| SCHEMBL18609350 | 0.85 | FGFR1 (0.56) | HPGDATMFGFR1GRK2GRK1 | |
| SCHEMBL18609278 | 0.84 | GABRP (0.43) | ATMGRK2GRK1GRK5 | |
| SCHEMBL16291053 | 0.82 | HTT (0.62) | HTTALDH1A1HPGDMAPK1MAPK10 | |
| SCHEMBL18609277 | 0.82 | FGFR1 (0.47) | ATMFGFR1GRK2GRK1GRK5 | |
| SCHEMBL18609354 | 0.80 | FGFR1 (0.59) | ATMFGFR1SRC | |
| SCHEMBL12822377 | 0.80 | GP6 (0.41) | ALDH1A1ATMGRK2GRK1GRK5 | |
| SCHEMBL22070428 | 0.80 | MAP3K8 (0.41) | HTTALDH1A1HPGDMAPK1MAPK10 | |
| SCHEMBL18584433 | 0.78 | HCAR1 (0.52) | ATMFGFR1GRK2GRK1GRK5 | |
| SCHEMBL19228785 | 0.77 | HTT (0.56) | HTTALDH1A1HPGDMAPK1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040993-A1 | SMALL MOLECULE INHIBITORS OF DYRK1A AND USES THEREOF | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2017-03-09 | — | — | WO | disclosed |