Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | PPIA | P62937 | 1/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18609414 | 0.88 | HDAC1 (0.57) | ALDH1A1RAF1LMNASMN1; SMN2PLA2G1B | |
| SCHEMBL18609585 | 0.88 | ALDH1A1 (0.49) | NAMPTPKMALDH1A1ROCK2ROCK1 | |
| SCHEMBL18609811 | 0.85 | NAMPT (0.46) | NAMPTPKMALDH1A1ROCK2ROCK1 | |
| SCHEMBL18609613 | 0.84 | MRGPRX4 (0.55) | LMNASMN1; SMN2 | |
| SCHEMBL18609592 | 0.80 | LMNA (0.51) | NAMPTPKMRAF1LMNASMN1; SMN2 | |
| SCHEMBL18609587 | 0.78 | NAMPT (0.49) | NAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL15574745 | 0.78 | RAF1 (0.59) | NAMPTALDH1A1RAF1LMNASMN1; SMN2 | |
| SCHEMBL18609581 | 0.77 | ALDH1A1 (0.45) | NAMPTALDH1A1ROCK2ROCK1LMNA | |
| SCHEMBL18609420 | 0.77 | MAPT (0.55) | ALDH1A1RAF1SMN1; SMN2BRAFPPARG | |
| SCHEMBL18610091 | 0.77 | KMT2A (0.45) | PKMALDH1A1RAF1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345892-A1 | UREA DERIVATIVE AND USE THEREFOR | Toray Industries, Inc. (JP) | 2018-07-11 | — | — | EP | disclosed |
| WO-2017038871-A1 | UREA DERIVATIVE AND USE THEREFOR | 東レ株式会社 | 2017-03-09 | — | — | WO | disclosed |