Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186742 | 0.95 | SIGMAR1 (0.41) | SIGMAR1POLBGAAPTK2ALDH1A1 | |
| SCHEMBL185704 | 0.94 | FASN (0.43) | SIGMAR1POLBGAAPTK2ALDH1A1 | |
| SCHEMBL185464 | 0.91 | SIGMAR1 (0.43) | SIGMAR1POLBGAAPTK2ALDH1A1 | |
| SCHEMBL185584 | 0.88 | SIGMAR1 (0.43) | SIGMAR1POLBGAAALDH1A1KMT2A | |
| SCHEMBL185364 | 0.88 | SIGMAR1 (0.45) | SIGMAR1POLBGAAPTK2ALDH1A1 | |
| SCHEMBL186322 | 0.86 | SIGMAR1 (0.45) | SIGMAR1POLBGAAALDH1A1L3MBTL1 | |
| SCHEMBL185935 | 0.85 | SIGMAR1 (0.43) | SIGMAR1POLBGAAALDH1A1L3MBTL1 | |
| SCHEMBL185809 | 0.85 | SIGMAR1 (0.45) | SIGMAR1POLBGAATYK2KMT2A | |
| SCHEMBL185673 | 0.83 | POLB (0.45) | SIGMAR1POLBGAAALDH1A1KMT2A | |
| SCHEMBL2809247 | 0.80 | ALDH1A1 (0.40) | POLBGAAALDH1A1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |