Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DDO | Q99489 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 4/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185854 | 0.83 | KDM4E (0.45) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL2805627 | 0.83 | KDM4E (0.45) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL2787773 | 0.82 | VNN1 (0.41) | ABL1BDKRB1GABRA1BACE1CYP1A2 | |
| SCHEMBL185748 | 0.82 | VNN1 (0.41) | ABL1BDKRB1GABRA1BACE1CYP1A2 | |
| SCHEMBL11984274 | 0.80 | BDKRB1 (0.39) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL185855 | 0.79 | KDM4E (0.41) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL12473747 | 0.75 | ABL1 (0.34) | ABL1GABRA1CYP1A2 | |
| SCHEMBL10070601 | 0.75 | SPHK1 (0.37) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL14856552 | 0.73 | HTR2A (0.33) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL185219 | 0.73 | KDM4E (0.53) | KDM4EMEN1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |