Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DDO | Q99489 | 1/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185854 | 1.00 | KDM4E (0.45) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL2809256 | 0.87 | KDM4E (0.48) | KDM4EALDH1A1CYP4F2CYP4A11HSD17B10 | |
| SCHEMBL2809274 | 0.87 | KDM4E (0.48) | KDM4EALDH1A1CYP4F2CYP4A11HSD17B10 | |
| SCHEMBL185219 | 0.86 | KDM4E (0.53) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL11984274 | 0.86 | BDKRB1 (0.39) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL2787462 | 0.84 | VNN1 (0.40) | BDKRB1CYP4F2CYP4A11GPR132BACE1 | |
| SCHEMBL186662 | 0.84 | VNN1 (0.40) | BDKRB1CYP4F2CYP4A11GPR132BACE1 | |
| SCHEMBL185595 | 0.84 | VNN1 (0.40) | BDKRB1CYP4F2CYP4A11GPR132BACE1 | |
| SCHEMBL186114 | 0.83 | KDM4E (0.43) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL10070601 | 0.81 | SPHK1 (0.37) | KDM4EMEN1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937073-B2 | Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-01-20 | — | — | US | disclosed |
| US-20130131075-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-23 | — | — | US | disclosed |
| US-20120208823-A1 | New Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-08-16 | — | — | US | disclosed |
| US-20100240669-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131075-A1 | NEW COMPOUNDS | ADORA1, H1-10, P2RY11 | KDM4E 4133/4885MEN1 314/4885ALDH1A1 1000/4885 |
| US-20120208823-A1 | New Compounds | ABCG2, SDHA, UGT2B7 | KDM4E 3647/4885MEN1 668/4885ALDH1A1 566/4885 |
| US-20100240669-A1 | NEW COMPOUNDS | ADORA1, H1-10, P2RY11 | KDM4E 4133/4885MEN1 314/4885ALDH1A1 1000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.