Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18613737 | 0.87 | ALDH1A1 (0.51) | ABL1ALDH1A1TDP1L3MBTL1KDM4E | |
| SCHEMBL18613664 | 0.83 | ABL1 (0.45) | ABL1ALDH1A1TDP1L3MBTL1HSD17B10 | |
| SCHEMBL16093814 | 0.81 | ABL1 (0.48) | ABL1ALDH1A1SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL18613974 | 0.81 | ALDH1A1 (0.51) | ABL1ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL27371781 | 0.80 | ALDH1A1 (0.58) | ALDH1A1TDP1L3MBTL1HSD17B10KDM4E | |
| SCHEMBL18613716 | 0.79 | ALDH1A1 (0.44) | ABL1ALDH1A1TDP1L3MBTL1HSD17B10 | |
| SCHEMBL18613862 | 0.79 | ALDH1A1 (0.44) | ABL1ALDH1A1TDP1L3MBTL1HSD17B10 | |
| SCHEMBL17483634 | 0.76 | ABL1 (0.50) | ABL1ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL18613936 | 0.76 | ABL1 (0.47) | ABL1ALDH1A1TDP1L3MBTL1KDM4E | |
| SCHEMBL18613962 | 0.75 | ABL1 (0.46) | ABL1ALDH1A1TDP1L3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190308934-A1 | Prodrugs of Chlorokynurenines | CEPHALON INC (US) | 2019-10-10 | — | — | US | disclosed |
| US-20190308934-A1 | Prodrugs of Chlorokynurenines | CEPHALON INC (US) | 2019-10-10 | — | — | US | disclosed |
| US-20180327351-A1 | PRODRUGS OF CHLOROKYNURENINES | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2018-11-15 | — | — | US | disclosed |
| EP-3347346-A1 | PRODRUGS OF CHLOROKYNURENINES | Cephalon, Inc. (US) | 2018-07-18 | — | — | EP | disclosed |
| WO-2017044516-A1 | PRODRUGS OF CHLOROKYNURENINES | CEPHALON, INC. (US) | 2017-03-16 | — | — | WO | disclosed |
| WO-2017044516-A1 | PRODRUGS OF CHLOROKYNURENINES | CEPHALON, INC. (US) | 2017-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190308934-A1 | Prodrugs of Chlorokynurenines | KMO, CYP2A13, KYNU | ABL1 901/4885ALDH1A1 724/4885TDP1 1739/4885 |
| US-20180327351-A1 | PRODRUGS OF CHLOROKYNURENINES | KMO, CYP2A13, KYNU | ABL1 901/4885ALDH1A1 724/4885TDP1 1739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.