Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 6/20 | 0.45 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | MC4R | P32245 | 2/20 | 0.43 |
| ▸ | MC5R | P33032 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | NPY4R | P50391 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL29220361 | 0.88 | KISS1R (0.47) | GHSRKISS1RNPY2R | |
| Tryptophan SCHEMBL7763177 | 0.87 | KDM4E (0.60) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL18614910 | 0.86 | KDM4E (0.52) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL18614911 | 0.86 | KDM4E (0.52) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28632232 | 0.86 | KDM4E (0.53) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL9617704 | 0.85 | KDM4E (0.63) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL27687187 | 0.85 | KDM4E (0.63) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL27657715 | 0.85 | KDM4E (0.52) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL27622241 | 0.84 | KMT2A (0.64) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL22635845 | 0.84 | KDM4E (0.64) | KDM4EMEN1LMNAMPOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112646004-A | 7 peptide for blocking CTLA4 in immunotherapy | 河南大学 | 2021-04-13 | — | — | CN | claimed |
| CN-112646004-A | 7 peptide for blocking CTLA4 in immunotherapy | 河南大学 | 2021-04-13 | — | — | CN | disclosed |