Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.38 |
| ▸ | CDK9 | P50750 | 7/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186390 | 0.93 | NAMPT (0.40) | KMT2AGRIN2BADAM10MMP1MMP2 | |
| SCHEMBL186475 | 0.82 | CCR2 (0.40) | GRIN2BKDM4EGRIN1NAMPT | |
| SCHEMBL186594 | 0.77 | MEN1 (0.40) | KMT2AGRIN2BCDK9CCNT1GRIN1 | |
| SCHEMBL186236 | 0.76 | TRPV1 (0.39) | GRIN2BMAPTNAMPTALDH1A1 | |
| SCHEMBL187256 | 0.72 | KDM4E (0.41) | GRIN2BKDM4EMAPTGRIN1 | |
| SCHEMBL186303 | 0.72 | ALDH1A1 (0.42) | KMT2AGRIN2BKDM4EMAPTGRIN1 | |
| SCHEMBL186850 | 0.70 | CCR2 (0.40) | GRIN2BGRIN1NAMPT | |
| SCHEMBL186248 | 0.70 | CCR2 (0.41) | GRIN2BGRIN1NAMPT | |
| SCHEMBL186245 | 0.68 | CCR2 (0.42) | KMT2AGRIN2BKDM4EGRIN1ALDH1A1 | |
| SCHEMBL186206 | 0.68 | SLC6A7 (0.44) | KMT2AGRIN2BKDM4EMAPTGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297148-B1 | NOVEL DERIVATIVES OF (BRIDGED PIPERAZINYL)-1-ALCANONE AND USE THEREOF AS P75 INHIBITORS | SANOFI SA (FR) | 2012-01-04 | — | — | EP | disclosed |